Chemical biology of hydrogen sulfide

Vascular biology of hydrogen sulfide.

Hydrogen sulfide (H2S) is a ubiquitous signaling molecule with important functions in many mammalian organs and systems. Observations in the 1990s ascribed physiological actions to H2S in the nervous system, proposing that this gasotransmitter acts as a neuromodulator. Soon after that, the vasodilating properties of H2S were demonstrated. In the past decade, H2S was shown to exert a multitude o...

Biology for Physiological Hydrogen Sulfide

On the chemical biology of the nitrite/sulfide interaction.

Sulfide (H2S/HS(-)) has been demonstrated to exert an astounding breadth of biological effects, some of which resemble those of nitric oxide (NO). While the chemistry, biochemistry and potential pathophysiology of the cross-talk between sulfide and NO have received considerable attention lately, a comparable assessment of the potential biological implications of an interaction between nitrite a...

Hydrogen sulfide, another simple gas with complex biology.

BACTERIAL INFECTIONS HAVE been one of the major scourges of humankind throughout history. Sepsis is recognized as a global health problem with an increasing incidence (5). The rate of hospitalization for sepsis more than doubled between 2000 and 2008 in the US (16). No monotherapy has been successful in improving mortality, including the recent failure of recombinant activated protein C to show...

Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.

BACKGROUND The potential biological significance of hydrogen sulfide (H(2)S) has attracted growing interest in recent years. The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] and evaluate its use as a tool to investigate the cardiovascular biology of this gas. METHODS AND R...